Rinholm Group

Our group is interested in the mechanisms of cell death and repair after an ischemic brain injury. We use a combination of in vivo mouse models, human brain organoids and organotypic mouse brain slices. Our methods include live confocal and multiphoton imaging, viral expression, RNA sequencing, immunohistochemistry and electron microscopy.

Ongoing projects:

• The role of lactate in ischemic brain injury and repair
• A human brain organoid model of cerebral ischemia
• Transplantation of brain organoids to repair brain injury after stroke
• The metabolic properties of oligodendrocytes
• Oxidation Resistance 1 (OXR1) in brain development and behavior