Strategies to Achieve the Goal

Our GEMINI centre on DRUGGING THE BRAIN aims to develop novel methods to target the blood-brain barrier which may help to drive progress in the field of neuroscience and brain tumors leading to new treatments for some of the most challenging and devastating neurological disorders. The Gemini centre facilitates close collaboration between SINTEF and academic co-applicants anchored at University of Oslo (UiO) for identifying and validating disease-causing protein alterations in neurological pathologies and to formulate promising drug candidates using novel nano-formulations for improved pharmacological effect better suited for crossing BBB. Moreover, it will facilitate further development and optimization of therapeutic ultrasound as a tool to facilitate localized drug delivery in the brain. Importantly, it will allow the research groups anchored at UiO access to these new technologies, developed at SINTEF, to deliver drugs to brain which they can test in the various brain pathology model ranging from Parkinson's disease to ischemia to brain tumors.